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Aronne LJ, Wadden TA, Peterson C, Winslow D, Odeh S, Gadde KM

Potential reproductive or systemic consequences have not been well studied, but theoretical risks include changes to hormonal feedback, timing of ovulation, and unintended effects on sperm or embryo development

This prespecified analysis assessed associations between baseline adiposity and MACE risk and examined whether early (week 20) and longer-term (week 104) changes in weight or waist circumference predicted subsequent MACE